He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. References. Monitoring: Hemodialysis, peritoneal dialysis: Data not available. -Infants 32 weeks or older GA and PNA 2 weeks or older: 30 mg/kg IV every 8 hours -Concentration of solution for IV bolus: Up to 50 mg/mL Re-constitute injection vials (500 mg and 1 gram) with sterile Water for Injection (see table 4 below). -Constituted solution for IV bolus: If unable to use freshly prepared solution immediately, may store up to 3 hours at up to 25C (77F) or for 13 hours at up to 5C (41F) Comments: MERREM IV should be administered by intravenous infusion over approximately 15 minutes to 30 minutes. MERREM IV should not be mixed with or physically added to solutions containing other drugs. Detailed Meropenem dosage information for adults and children. Pediatric Patients 3 Months of Age and Older, Pediatric Patients Less Than 3 Months of Age. -Hematologic: Hematopoietic organ system functions (periodically during prolonged therapy) This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. No dose adjustment is necessary in patients with hepatic impairment (see section 4.4). Applies to the following strengths: 500 mg; 1000 mg; 500 mg/ 50 mL-NaCl 0.9%; 1000 mg/ 50 mL-NaCl 0.9%, 500 mg IV every 8 hours Publishers of the British National Formulary. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. We comply with the HONcode standard for trustworthy health information -. -Compatible for IV infusion: Sodium Chloride Injection 0.9%, Dextrose Injection 5% TDM-monograph Meropenem October 2015, CONCEPT version Page 4 of 5 meropenem 500 mg every 8 hours, or 1 gram every 6 hours in patients with normal renal function. Comments: Active ingredients Size Unit NHS indicative price Drug tariff Drug tariff price; Meropenem (as Meropenem trihydrate) 500 mg; 10: vial (POM) £103.14 (Hospital only) Part VIIIA Category C Storage requirements: -Effective in eliminating concurrent bacteremia associated with bacterial meningitis. CrCl >60 mL/min: No dosage adjustment necessary; CrCl 21-60 mL/min: 260 mg/day PO; CrCl ≤20 mL/min or continuous peritoneal dialysis : 200 mg/day PO; Dosing Considerations The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Directions for administration For continuous intravenous infusion , manufacturer advises reconstitute each 1 g (as meropenem) vial to produce a 0.05 g (as meropenem)/mL solution with 20 mL Sodium Chloride 0.9%. Shake to dissolve and let stand until clear. IV compatibility: Economic benefit of a meropenem dosage strategy based on pharmacodynamic concepts. Meropenem Merrem ® - Renal dosing. NDA 50-706/S-022 Page 4 concentrations of meropenem in excess of … The safety profile of meropenem in the elderly (aged > 65 years, n=843) and/or renally impaired (creatinine clearance < 51 ml/min, n=436) was assessed by evaluating data from 26 phase III studies which compared the use of meropenem (0.5 or 1.0 g, i.v. Select one or more newsletters to continue. Meropenem is cleared by haemodialysis and haemofiltration. -For IV infusion: May constitute infusion vials directly with compatible infusion fluid; alternatively, may constitute an injection vial, add the resulting solution to an IV container, then further dilute with an appropriate infusion fluid [35489] [63245] One trial of 47 patients with a mean age of 2 years (range, 4 days to 20 years) examined meropenem 20 mg/kg/dose (or up to 40 mg/kg/dose for CNS or critical infections) IV every 8 hours for a variety of infections. -Solution for IV infusion when constituted with Sodium Chloride Injection 0.9%: If unable to use freshly prepared solution immediately, may store for 1 hour at up to 25C (77F) or 15 hours at up to 5C (41F) Compatibility of MERREM IV with other drugs has not been established. Page 1 of 3 King Edward Memorial Hospital & Perth Children’s Hospital Neonatology Meropenem - Neonatal NEONATAL MEROPENEM This document should be read in conjunction with this DISCLAIMER Restricted: Requires Microbiologist review within 24 hours of initiation Presentation Vial: 500mg Classification Bactericidal carbapenem antibiotic. Plasma concentrations of meropenem for neonates, infants and children after a single dose of 20 or 40 mg/kg (Ped Infec Dis J 1997; 16:263-8) CSF concentrations are approximately 15% of the simultaneous serum concentrations during the first 1 to 4 h after IV infusion during the first 24 to 48 h of therapy in children with meningitis -Hepatic: Hepatic organ system functions (periodically during prolonged therapy) -Pediatric patients younger than 3 months: Administer as IV infusion over 30 minutes. Hepatic impairment. CrCl less than 10 mL/min: One-half recommended dose every 24 hours Should you take probiotics with antibiotics. 400 mg/day PO in single daily dose or divided q12hr. -Complicated infections due to Pseudomonas aeruginosa: 1 g IV every 8 hours Use normal dose every 12 hours if eGFR 26–50 mL/minute/1.73 m 2. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. -Do not use flexible container in series connections. Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. -Efficacy as monotherapy in the treatment of meningitis due to penicillin nonsusceptible isolates of S pneumoniae has not been established. HML restricted (accepted in SSH and CHCH and shared care centres on National Febrile Neutropenia protocol). It is resistant to some forms of extended-spectrum beta-lactamase. Includes dosages for Skin and Structure Infection, Intraabdominal Infection, Nosocomial Pneumonia and more; plus renal, liver and dialysis adjustments. Use normal dose every 12 hours if estimated glomerular filtration rate 26–50 mL/minute/1.73 m 2.. Use half normal dose every 12 hours if estimated glomerular filtration rate 10–25 mL/minute/1.73 m 2.. Use half normal dose every 24 hours if estimated glomerular filtration rate less than 10 mL/minute/1.73 m 2. Uses: As a single agent therapy for the treatment of complicated intraabdominal infections (including appendicitis and peritonitis) due to viridans group streptococci, E coli, Klebsiella pneumoniae, P aeruginosa, B fragilis, B thetaiotaomicron, Peptostreptococcus species, Infectious Diseases Society of America (IDSA) recommendations: 2 g IV every 8 hours for 7 to 21 days Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. Select one or more newsletters to continue. When treating complicated skin and skin structure infections caused by P. aeruginosa, a dose of 1 gram every 8 hours is recommended. -Concentration of solution for IV infusion: Ranges from 1 to 20 mg/mL Duration of therapy: As short as 7 days recommended (reducing from traditional 14 to 21 days) if causative organism is not P aeruginosa and patient has good clinical response 3 months or older: 10 mg/kg IV every 8 hours Vancomycin 15 mg/kg (500 mg) IV 6H and Meropenem 20 mg/kg (1 g) IV 8H and Clindamycin 15 mg/kg (600 mg) IV 8H. The recommended dose of MERREM IV is 500 mg given every 8 hours for skin and skin structure infections and 1 gram given every 8 hours for intra-abdominal infections. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Last updated on Sep 22, 2020. Antibiotics & Drinking Alcohol - Is it Safe? -Compatibility with other drugs not established; this drug should not be mixed with or physically added to solutions containing other drugs. Meropenem undergoes both filtration and tubular secretion. Administration advice: -Renal: Renal organ system functions (periodically during prolonged therapy); renal function in elderly patients Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. CrCl 10 to 25 mL/min: One-half recommended dose every 12 hours Uses: As a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, S agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), P aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, Peptostreptococcus species, 1 g IV every 8 hours Reconstitution/preparation techniques: Maximum dose: 1 g/dose Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Maximum dose: 2 g/dose -Complicated infections due to P aeruginosa: 20 mg/kg IV every 8 hours It is available for oral use. The required dose should be administered after completion of the haemodialysis cycle. Dosage should be reduced in patients with creatinine clearance of 50 mL/min or less. -Dry powder: Store at controlled room temperature 20C to 25C (68F to 77F) -Infants less than 32 weeks gestational age (GA) and postnatal age (PNA) less than 2 weeks: 20 mg/kg IV every 12 hours See dosing table 2 below. -Do not operate machinery or motorized vehicles until it is reasonable well established that this drug is well tolerated. -Compatible for IV bolus: Sterile Water for Injection This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Comments: Alternatively, an injection vial may be re-constituted, then the resulting solution added to an intravenous container and further diluted with an appropriate infusion fluid. resistant to other antibiotics. -General: Organ system functions (periodically during prolonged therapy) Four hundred forty-six patients (397 pediatric patients 3 months to less than 17 years of age) were enrolled in 4 separate clinical trials and randomized to treatment with meropenem (n=225) at a dose of 40 mg/kg every 8 hours or a comparator drug, i.e., cefotaxime (n=187) or ceftriaxone (n=34), at the approved dosing regimens. Pediatric patients: Data not available. However, re-constituted solutions of MERREM IV maintain satisfactory potency under the conditions described below. -Solution for IV infusion when constituted with Dextrose Injection 5%: Freshly prepared solution should be used immediately. Meropenem clearance increases with gestational age and chronologic age as the kidneys mature. Uses: As a single agent therapy for the treatment of bacterial meningitis due to S pneumoniae, Haemophilus influenzae, Neisseria meningitidis -This drug is useful as presumptive therapy in the indicated condition before causative organism is identified due to broad spectrum of bactericidal activity. -Infants 32 weeks or older GA and PNA less than 2 weeks: 20 mg/kg IV every 8 hours Solutions of intravenous MERREM IV should not be frozen. There is inadequate information regarding the use of MERREM IV in patients on hemodialysis or peritoneal dialysis. Greater than 50 mL/min: Recommended dose every 8 hours -Shortening the duration of therapy may reduce the risk of superinfections with resistant organisms. (See dosing table below.). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Dental abscess : ... Gentamicin once-daily dosing. Solutions prepared for infusion (MERREM IV concentrations ranging from 1 mg/mL to 20 mg/mL) re-constituted with Dextrose Injection 5% should be used immediately.